Thyroid hormone action on skin.
Level 5 - mechanism / opinion, no new human data
Narrative review or mechanism-based description with no original clinical trial or empirical human data
PubMed 22110782 · doi:10.4161/derm.3.3.17027
What was done
Descriptive narrative overview of the cutaneous features and pathophysiological mechanisms associated with thyroid hormone deficiency, focusing on generalized myxedema.
What was found
The abstract reports no numerical values or statistical findings. It notes qualitatively that generalized myxedema in hypothyroidism is caused by increased dermal deposition of glycosaminoglycans and acid mucopolysaccharides (specifically hyaluronic acid), and that the resulting skin changes do not pit with pressure.
Why it matters
It summarizes the classic dermatological manifestations and underlying extracellular matrix changes seen in hypothyroidism.
Limits
The abstract contains no empirical data, sample size, comparator, or systematic review methodology, representing purely descriptive commentary.
Cited by
- supports Hypothyroidism causes myxedema, characterized by visible thickening and swelling of the face, neck, skin, and back of the arms rather than just adipose tissue.