Friedman · Disease models & mechanisms 2012 · expert interview / historical narrative · n=?

Leading the charge in leptin research: an interview with Jeffrey Friedman.

Cited 16 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Expert interview and historical retrospective containing no original empirical data

PubMed 22915017 · doi:10.1242/dmm.010629 · record verified 2026-08-29

What was done

This publication is an interview with molecular geneticist Jeffrey Friedman, recounting the 1994 discovery of leptin and providing personal perspectives on future directions in obesity research.

What was found

The abstract reports no quantitative data or experimental results, functioning entirely as a historical overview and expert commentary.

Why it matters

It provides historical context and scientific perspective from the discoverer of leptin, a key hormone regulating feeding behavior and body weight.

Limits

As an interview and historical reflection, the piece provides no new experimental or clinical data, controls, statistical testing, or systematic synthesis of the literature.

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