Gastric peptides and their regulation of hunger and satiety.
Level 5 - mechanism / opinion, no new human data
Narrative review of physiological mechanisms without systematic search methodology or original clinical trial data.
PubMed 23001831 · doi:10.1007/s11894-012-0291-3
What was done
This is a narrative review describing the physiological role of gastric endocrine cells, particularly gastric X/A-like cells, in hunger and satiety gut-brain signaling. The authors synthesize mechanistic literature on gastric peptides including ghrelin, desacyl ghrelin, obestatin, and nesfatin-1.
What was found
The abstract reports no numerical or quantitative data. Qualitatively, it notes that ghrelin is a peripheral orexigenic hormone, desacyl ghrelin may counter-regulate ghrelin's food intake stimulation, obestatin's proposed anorexigenic property failed confirmation in subsequent studies, and gastric nesfatin-1 acts as an anorexigenic peptide, establishing the stomach as a dual regulator of food intake.
Why it matters
It emphasizes that gastric endocrine signaling is bidirectional rather than purely orexigenic, providing a foundation for understanding gut-derived regulation of energy balance.
Limits
This is a narrative review that provides no sample size, search protocol, or quantitative data. The abstract does not distinguish between human clinical findings and animal or bench models.
Cited by
- supports Ghrelin is the only gut-derived hormone that stimulates hunger.