Prime-, stress-, and cue-induced reinstatement of extinguished drug-reinforced responding in rats: cocaine as the prototypical drug of abuse.
Level 5 - mechanism / opinion, no new human data
Preclinical laboratory protocol and animal model description with no human clinical data.
PubMed 23093352 · doi:10.1002/0471142301.ns0939s61
What was done
The unit describes standardized experimental protocols for evaluating prime-, footshock (stress)-, and cue-induced reinstatement of extinguished drug-reinforced responding in rats, using cocaine self-administration as the prototypical model.
What was found
The abstract reports no numerical findings, effect sizes, or experimental data; it outlines the methodology for comparing test compounds against vehicles or assessing strain differences in drug-seeking behavior.
Why it matters
Standardized animal protocols for reinstatement provide reproducible methods to evaluate pharmacotherapies and genetic factors involved in distinct triggers of drug relapse.
Limits
The abstract contains no empirical results, statistical data, or sample sizes. Reinstatement paradigms in rodents only approximate complex human addiction and relapse behaviors.
Cited by
- supports In rodent experiments where cocaine self-administration has been extinguished, applying a severe physical stressor such as a painful foot shock causes the rodent to immediately resume lever-pressing for cocaine.