Bowen · Odontology 2013 · narrative review · n=?

The Stephan Curve revisited.

Cited 141 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review and conceptual commentary without primary data or systematic methodology

PubMed 23224410 · doi:10.1007/s10266-012-0092-z · record verified 2026-08-28

What was done

Narrative review evaluating the historical role and limitations of the Stephan Curve in caries research, focusing on plaque pH measurement methods, intra-plaque pH heterogeneity, and biological interactions following sugar exposure.

What was found

The abstract reports no numerical or quantitative findings. It reports that plaque pH measurements can give a false sense of accuracy because multiple pH values exist across the plaque matrix, and argues that using fixed critical pH thresholds to label foods as safe overlooks important biological mechanisms, particularly protective alkali production.

Why it matters

Highlights that caries pathogenesis extends beyond simple acid dissolution curves and points to plaque alkali production as a neglected research and therapeutic target.

Limits

No primary clinical or laboratory data are presented, no quantitative outcomes are reported, and no systematic search or study inclusion criteria are described.

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