eXclusion: toward integrating the X chromosome in genome-wide association analyses.
Level 5 - mechanism / opinion, no new human data
Commentary and narrative methodological review without systematic quantitative synthesis.
PubMed 23643377 · doi:10.1016/j.ajhg.2013.03.017
What was done
This commentary reviewed results in the NHGRI GWAS Catalog regarding the representation of X chromosome associations, investigated commonly cited reasons for excluding the X chromosome from GWAS, evaluated available analytical tools, and proposed recommendations for integrating the X chromosome into future association studies.
What was found
The abstract reports no numerical findings. It notes that reported X chromosome hits lag substantially behind autosomal findings and that the X chromosome is routinely excluded from analyses despite being assayed on modern genotyping microarrays.
Why it matters
Excluding the X chromosome from genome-wide scans leaves a meaningful portion of the human genome uncharacterized for complex traits. This paper highlights existing analytical tools and recommendations to encourage routine X chromosome inclusion.
Limits
The abstract describes a commentary and narrative review rather than primary experimental research or a quantitative meta-analysis. No specific numbers, counts of catalog entries, or statistical metrics are reported in the abstract.
Cited by
- supports Most genetic studies focus exclusively on the autosomes and exclude the sex chromosomes from analysis.