Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy.
Level 5 - mechanism / opinion, no new human data
Narrative review and mechanism-based theoretical framework without primary human trial data.
PubMed 23651186 · doi:10.1111/nyas.12105
What was done
The authors review the conceptual framework and evidence from animal models and human cancer for cancer immunoediting, detailing its three phases (elimination, equilibrium, and escape) and the role of CD8+ T-cell selection in immune escape.
What was found
The abstract presents a theoretical framework and qualitative synthesis; no quantitative experimental data, sample sizes, or numerical outcomes are reported.
Why it matters
It outlines how immune pressure actively selects for antigen-deficient tumor variants, providing the mechanistic rationale for targeted and personalized cancer immunotherapies.
Limits
The abstract describes a narrative overview rather than a systematic review or empirical study, providing no methodology, quantitative metrics, or clinical sample parameters.
Cited by
- supports The human immune system actively identifies and eliminates emerging cancer cells on a daily basis.