Chemokine systems link obesity to insulin resistance.
Level 5 - mechanism / opinion, no new human data
Narrative review of biological mechanisms and pathways without primary empirical data
PubMed 23807918 · doi:10.4093/dmj.2013.37.3.165
What was done
This narrative review synthesized literature on the role of chemokine systems and adipose tissue macrophages in mediating obesity-induced chronic low-grade inflammation and insulin resistance.
What was found
The abstract reports no empirical data or statistical findings. It notes that over 50 chemokines and 18 chemokine receptors have been identified, highlighting the role of C-C motif chemokine receptor 2 (CCR2) and monocyte chemoattractant protein-1 (MCP-1) in adipose tissue macrophage accumulation while emphasizing substantial functional redundancy across chemokine networks.
Why it matters
Understanding the chemokine pathways driving macrophage infiltration into adipose tissue helps map the molecular link between obesity, chronic inflammation, and type 2 diabetes.
Limits
The abstract describes a narrative review without primary clinical data, quantitative effect estimates, or systematic search methods; functional redundancy among chemokine pathways also limits clear delineation of individual receptor contributions.
Cited by
- supports Individuals with obesity have higher circulating levels of pro-inflammatory cytokines and chemokines.