Sirtuins in stress response: guardians of the genome.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic research and mouse knockout models without primary human data.
PubMed 23995787 · doi:10.1038/onc.2013.344
What was done
This narrative review synthesized laboratory findings and evidence from mouse knockout models for all seven mammalian sirtuins (SIRT1–7) to examine their roles in metabolic homeostasis, cell-cycle control, survival pathways, and genome maintenance under stress.
What was found
The abstract reports no quantitative values or statistical effect sizes. It qualitatively describes evidence that mammalian sirtuins protect genome stability during stress responses, predominantly through direct roles in chromatin-related functions affecting cellular physiology and tumorigenesis.
Why it matters
It consolidates mechanistic pathways linking NAD(+)-dependent deacetylation to genomic maintenance, highlighting potential targets for understanding and intervening in stress-related diseases and cancer.
Limits
The paper is an unsystematic narrative review with no direct human clinical data, no quantitative metrics reported in the abstract, and primary reliance on animal and mechanistic models.
Cited by
- supports Sirtuin enzymes require nicotinamide adenine dinucleotide (NAD) to carry out their deacetylation reaction.