Haastrup · Basic & clinical pharmacology & toxicology 2014 · systematic review · n=41 studies

Alcohol and breastfeeding.

Cited 114 times in the scientific literature.

Level 1 - systematic review of randomized trials

Systematic review of published human pharmacokinetic, observational, and experimental studies

PubMed 24118767 · doi:10.1111/bcpt.12149 · record verified 2026-08-26

What was done

Systematic review of literature indexed in PubMed from inception to May 2013 on maternal alcohol consumption during lactation. The authors assessed prevalence, milk ejection reflex and yield, alcohol pharmacokinetics in lactating women and nursing infants, and reported infant outcomes across 41 included publications.

What was found

Approximately half of lactating women in Western countries report alcohol intake. Alcohol concentrations in breast milk closely track maternal blood levels. Nursing infants receive an estimated 5-6% of the weight-adjusted maternal dose and clear alcohol at roughly half the adult metabolic rate. Alcohol temporarily inhibits the milk ejection reflex, reducing milk yield. Reported infant behavioral changes are minor and contradictory across studies, with no clear evidence of adverse effects from occasional maternal drinking.

Why it matters

Synthesizes pharmacokinetic and clinical data showing low infant systemic exposure to alcohol through breast milk during typical maternal intake, supporting guidance aligned with standard adult drinking recommendations.

Limits

The literature search was restricted to a single database (PubMed). Studies assessing infant outcomes are limited, contradictory, and lack data on long-term effects of heavy maternal alcohol abuse.

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