Association between genetic variations in the insulin/insulin-like growth factor (Igf-1) signaling pathway and longevity: a systematic review and meta-analysis.
Level 3 - non-randomized controlled study
Systematic review and meta-analysis of observational genetic association studies
PubMed 24350933 · doi:10.2174/1570161111666131218152807
What was done
The authors conducted a systematic review and meta-analysis using a model-free approach across 11 studies to assess associations between human longevity and polymorphisms in four insulin/IGF-1 signaling pathway genes: IGF-1, IGF-1R, FOXO3A, and SIRT1.
What was found
The abstract reports directions and significance but no numerical effect sizes, odds ratios, or confidence intervals. Meta-analysis of 4 studies found a significant association between the IGF-1R rs2229765 A-bearing genotype and longevity. For FOXO3A (5 studies), significant associations were found for rs2764264 (C allele in males), rs2802292 (G allele), rs9400239 (T allele, reported with lower odds ratio in long-lived males than centenarians), and rs479744 (A allele in centenarians). Single studies for IGF-1 and SIRT1 found no significant associations with longevity.
Why it matters
This review synthesizes genetic association data linking specific IGF-1R and FOXO3A variants to human longevity phenotypes.
Limits
The abstract omits exact participant counts, odds ratios, and confidence intervals. Findings are limited by a small number of included studies per gene, observational designs, and reported high between-study heterogeneity.
Cited by
- supports Genetic polymorphisms in the IGF-1 receptor and FOXO genes are associated with human longevity.
- supports The FOXO3 gene is well known to be associated with longevity and supercentenarians.