Eisenberger · Annual review of psychology 2015 · narrative review · n=?

Social pain and the brain: controversies, questions, and where to go from here.

Cited 371 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review synthesizing theory and literature without systematic review methodology or new human data

PubMed 25251482 · doi:10.1146/annurev-psych-010213-115146 · record verified 2026-08-29

What was done

Narrative review summarizing research on the physical-social pain overlap hypothesis and synthesizing available evidence to address three criticisms: that neural responses reflect conflict detection rather than distress, that pain-related activations reflect general negative affect rather than social pain specifically, and that responses reflect salience rather than hurt.

What was found

The abstract reports no numerical or quantitative data. It presents a qualitative, conceptual synthesis supporting shared neural systems between physical and social pain while addressing competing neurocognitive explanations.

Why it matters

This paper frames the theoretical and empirical case for shared neural substrates underlying physical injury and social rejection, clarifying core debates in affective neuroscience.

Limits

Narrative review design without systematic search protocols, quantitative synthesis, or reported study counts. No primary empirical data or statistical estimates are provided in the abstract.

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