Overnutrition, mTOR signaling, and cardiovascular diseases.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanistic pathways without primary human data or systematic methodology.
PubMed 25253086 · doi:10.1152/ajpregu.00262.2014
What was done
This narrative review summarizes literature examining how excessive intake of carbohydrates and fats enhances mammalian target of rapamycin (mTOR) signaling and contributes to metabolic, cardiovascular, and renal pathologies.
What was found
The abstract reports no numerical data or quantitative effect sizes. It describes qualitative associations where excess nutrient consumption stimulates mTOR pathway activity, leading to altered metabolic signaling, insulin resistance, type 2 diabetes, hypertension, cardiovascular disease, kidney disease, and cancer.
Why it matters
It conceptualizes mTOR signaling as a key nutrient sensor linking overnutrition to cardiorenal metabolic disorders, outlining potential pathways for targeted therapeutic strategies.
Limits
As a narrative review, it lacks primary human experimental data, quantitative synthesis, or systematic search methodology. Precise cellular mechanisms linking enhanced mTOR signaling to specific end-organ damage remain unresolved.
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