The role of gut hormones in appetite regulation (review).
Level 5 - mechanism / opinion, no new human data
Narrative review of physiological mechanisms without systematic search or primary data
PubMed 25532952 · doi:10.1556/APhysiol.101.2014.4.1
What was done
Narrative review examining the physiological mechanisms and neuroendocrine pathways through which gut-derived hormones regulate homeostatic and hedonic components of appetite and energy balance.
What was found
The abstract reports no quantitative data or effect estimates. It summarizes physiological signaling pathways wherein enteroendocrine peptides communicate to the hypothalamus via the bloodstream or vagal nerve inputs to the nucleus of the solitary tract. Ghrelin and gut-derived endocannabinoids act as orexigenic drivers of food intake and body weight, while cholecystokinin, glucagon-like peptide-1, oxyntomodulin, peptide YY, and pancreatic polypeptide function as anorexigenic signals.
Why it matters
Provides an overview of peripheral-to-central gut signaling pathways that serve as foundational targets for pharmacotherapy and peptide analogues in obesity treatment.
Limits
As a narrative review, it lacks a systematic search strategy, quality appraisal of included studies, and quantitative synthesis. The abstract presents no primary experimental data, clinical outcomes, or safety and tolerability metrics for specific therapeutic analogues.
Cited by
- supports Ghrelin is the only gut-derived hormone that stimulates hunger.