Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation.
Level 5 - mechanism / opinion, no new human data
Narrative review of biophysical mechanisms and theoretical models without systematic methodology.
PubMed 25939984 · doi:10.1007/s00249-015-1025-x
What was done
This narrative review synthesizes theoretical and biophysical models of molecule electrotransfer through cell membranes. It evaluates the concept of transient hydrophilic aqueous pore formation in single-cell and cell-suspension models and outlines considerations for drug and gene delivery alongside clinical trial applications.
What was found
The abstract reports no numerical findings or statistical measures. It qualitatively describes mechanisms of membrane electroporation, hydrophilic pore dynamics, and aspects of drug and gene electrotransfer.
Why it matters
It provides a conceptual overview linking theoretical membrane biophysics with practical drug and gene delivery applications in clinical settings.
Limits
The abstract describes a narrative review without systematic search methods, quantitative data synthesis, or new empirical findings. Sample size, study selection criteria, and specific clinical outcomes are not reported.
Cited by
- supports Electroporation delivers genetic materials or protein-RNA complexes into cells by passing an electrical current that creates transient pores in the cell membrane.