Magnesium in Prevention and Therapy.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanisms and clinical associations without systematic methodology
PubMed 26404370 · doi:10.3390/nu7095388
What was done
This paper is a narrative review detailing the physiological mechanisms of magnesium in human biology (including ATP metabolism, DNA/RNA synthesis, and neuromuscular regulation) and summarizing clinical associations between hypomagnesemia and various chronic diseases.
What was found
No quantitative findings, statistical analyses, or trial data are reported in the abstract. Magnesium is noted as the fourth most abundant mineral in the body and a cofactor for over 300 enzymatic reactions. Low magnesium levels are qualitatively described as associated with Alzheimer's disease, insulin resistance, type-2 diabetes mellitus, hypertension, stroke, migraine headaches, and attention deficit hyperactivity disorder.
Why it matters
It provides a broad overview of magnesium's biological necessity and catalogues the diverse disease states where magnesium deficiency may play a role.
Limits
The abstract contains no primary data, systematic search criteria, or quantitative effect sizes. Observational associations mentioned do not establish causality, and specific intervention protocols or clinical outcomes are not described.
Cited by
- supports Magnesium is an essential enzymatic cofactor for more than 300 enzymes in the human body.