Exercise and Regulation of Carbohydrate Metabolism.
Level 5 - mechanism / opinion, no new human data
Narrative review/chapter discussing molecular mechanisms without systematic search methods or primary empirical data.
PubMed 26477909 · doi:10.1016/bs.pmbts.2015.07.020
What was done
This chapter reviewed the evolutionary context of carbohydrate metabolism, the impact of sedentary lifestyles and high-carbohydrate diets on type 2 diabetes risk, and the molecular mechanisms by which physical activity regulates skeletal muscle glucose uptake and systemic glucose homeostasis.
What was found
The abstract reports no numerical data. It notes that carbohydrates serve as the preferred fuel during high-intensity exercise and are readily utilized during moderate exercise. It highlights that exercise and insulin activate distinct proximal signaling pathways to stimulate glucose uptake, enabling exercise to enhance glucose disposal even under conditions of insulin resistance.
Why it matters
It outlines the physiological basis for exercise as a therapeutic intervention in type 2 diabetes, showing how contractile activity can bypass impaired insulin pathways to clear circulating glucose.
Limits
The abstract describes a narrative overview without primary empirical data, sample sizes, or systematic review methodology. Specific signaling intermediates and concrete exercise dose-response parameters are not detailed in the abstract.
Cited by
- supports Exercise increases glucose transport capacity into muscle and lowers chronically high blood sugar by increasing cell membrane glucose transporters.