Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice.
Level 5 - mechanism / opinion, no new human data
Bench and animal research (in vitro cell assays and mouse models)
PubMed 26645687 · doi:10.1074/jbc.M115.676510
What was done
The authors evaluated the role of acetoacetate on muscle cell proliferation and muscle regeneration. They tested acetoacetate in normal mice and in mdx mice (a mouse model of muscular dystrophy). Multiparameter molecular analyses were performed to identify the downstream signaling pathway.
What was found
Acetoacetate promoted muscle cell proliferation, accelerated muscle regeneration in normal mice, and ameliorated muscular dystrophy in mdx mice via activation of the MEK1-ERK1/2-cyclin D1 pathway. No quantitative values, sample sizes, or effect sizes were reported in the abstract.
Why it matters
This study identifies a non-metabolic signaling role for acetoacetate in muscle cell regulation, pointing to potential therapeutic avenues for muscle regeneration and dystrophies.
Limits
The study is entirely preclinical (in vitro and mouse models) with unknown direct applicability to human clinical conditions. The abstract provides no quantitative data, sample sizes, dosing regimens, or statistical measures.
Cited by
- supports Acetoacetate stimulates skeletal muscle regeneration in muscular dystrophy through an ERK-MEK-cyclin D signaling pathway.