Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Level 5 - mechanism / opinion, no new human data
Global expert consensus statement and clinical practice guideline based on systematic review.
PubMed 26745253 · doi:10.1210/jc.2015-2175
What was done
A systematic literature search was conducted covering the definition, diagnosis, treatment, and prevention of nutritional rickets in children. A panel of 33 nominated experts in pediatric endocrinology, pediatrics, nutrition, epidemiology, public health, and health economics across 11 international scientific organizations evaluated the evidence in five working groups. Recommendations were formulated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework during a multiday consensus conference in May 2014.
What was found
The abstract reports no numerical values or quantitative outcome metrics. The consensus document established definitions and diagnostic criteria for nutritional rickets, outlined clinical management for rickets and osteomalacia, ranked risk factors in mothers and infants, and produced recommendations for supplementation and food fortification in clinical and public health contexts.
Why it matters
Nutritional rickets and osteomalacia remain widespread, preventable causes of impaired development and mortality globally. This document provides unified, evidence-based guidance to standardize clinical practice and guide policymakers in formulating prevention programs.
Limits
The abstract does not provide the specific search parameters, number of studies evaluated, evidence quality scores, or concrete dosing and diagnostic thresholds. As a consensus statement, it reflects panel synthesis and judgment rather than new primary experimental data.
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