Type 2 diabetes mellitus.
Level 5 - mechanism / opinion, no new human data
Narrative review with no primary empirical data or systematic search methodology
PubMed 27189025 · doi:10.1038/nrdp.2015.19
What was done
This is a narrative disease primer reviewing the epidemiology, pathophysiology, complications, and treatment strategies of type 2 diabetes mellitus (T2DM).
What was found
The abstract provides no quantitative data or statistical findings. It outlines the core defects of insulin resistance and impaired insulin secretion alongside six additional pathophysiological abnormalities, concluding that multi-agent combination therapy is necessary to achieve normoglycaemia.
Why it matters
It provides a broad clinical framework emphasizing that T2DM pathogenesis requires multi-targeted combination therapies and agents capable of halting progressive beta-cell decline.
Limits
As a narrative review, it lacks a systematic literature search methodology, quantitative meta-analysis, and primary experimental data. No sample sizes or effect estimates are reported in the abstract.
Cited by
- context In the progression of insulin resistance, the pancreas produces increasingly high levels of insulin to compensate, and blood sugar only rises once the insulin stops working effectively.