Small Molecules as SIRT Modulators.
Level 5 - mechanism / opinion, no new human data
Narrative review of preclinical and medicinal chemistry literature with no primary human data or systematic methodology.
PubMed 27334466 · doi:10.2174/1389557516666160620095103
What was done
This narrative medicinal chemistry review summarizes literature on natural and synthetic small molecules identified via high-throughput screening and medicinal chemistry techniques that activate or inhibit mammalian sirtuin deacetylases (SIRT1–7).
What was found
The abstract reports that natural polyphenols (resveratrol, fisetin, quercetin) function as SIRT1 activators, while diverse synthetic modulators (including SRT1720, SRT1460, Selisistat, and AGK2) display modulatory potencies with IC50 values ranging from 0.04 to 100 μM. No quantitative human clinical outcomes are reported.
Why it matters
It outlines the chemical diversity and potency ranges of small-molecule sirtuin modulators developed as pharmacological probes and potential therapeutics for metabolic, cardiovascular, neurodegenerative, and age-related conditions.
Limits
The review relies on preclinical in vitro and animal data without presenting human clinical trial outcomes. As a non-systematic narrative review, study selection criteria, risk of bias, and comprehensive search parameters are not reported.
Cited by
- supports Polyphenols such as resveratrol and quercetin hyperactivate sirtuins, with NAD serving as the essential cofactor.