Models of energy homeostasis in response to maintenance of reduced body weight.
Level 4 - case-series / case-control
Uncontrolled prospective before-and-after physiological study (case series / pre-post design)
PubMed 27460711 · doi:10.1002/oby.21559
What was done
Evaluated three models of adaptive thermogenesis across energy expenditure compartments in 17 inpatient individuals with obesity. Resting energy expenditure (REE) and non-resting energy expenditure (NREE) were measured at usual weight, and subsequently after maintaining a 10% and a 20% weight loss.
What was found
The abstract reports no numerical values or exact statistics. Following a 10% weight loss, both REE and NREE dropped significantly below predicted values based on lost mass and composition. An additional 10% weight loss resulted in further reductions below predicted values for NREE, but not for REE. Changes in body weight, composition, and energy stores significantly correlated with changes in energy expenditure.
Why it matters
Shows that components of energy expenditure adapt differently to weight loss, with REE following a threshold response and NREE adapting proportionally to the degree of weight lost.
Limits
Small sample size (n = 17) and an uncontrolled, single-arm inpatient design. The abstract reports no numerical data, confidence intervals, or exact p-values. Inpatient conditions may not fully represent free-living long-term weight maintenance.
Cited by
- supports Losing 10% of body weight causes an average 15% decline in basal metabolic rate beyond what is expected from lost mass.