iPS Cells 10 Years Later.
Level 5 - mechanism / opinion, no new human data
Historical commentary and expert perspective with no primary empirical data (design analogy).
PubMed 27610558 · doi:10.1016/j.cell.2016.08.043
What was done
A retrospective discussion and interview organized by Cell editor João Monteiro, convening Shinya Yamanaka and Hans Schöler (one of the original reviewers) to discuss the history and legacy of the 2006 landmark discovery of induced pluripotent stem cells (iPSCs).
What was found
The abstract reports no empirical data or statistical results. It outlines a reflective conversation detailing the historical context, peer review, and scientific impact of the 2006 Takahashi and Yamanaka breakthrough.
Why it matters
It documents firsthand historical insights from the lead discoverer and an initial reviewer regarding the development and trajectory of cellular reprogramming over its first decade.
Limits
The publication is an editorial retrospective and narrative interview rather than an empirical research study or systematic review; it presents no new experimental or quantitative data.
Cited by
- supports The Yamanaka factors, which allow reprograming a somatic cell into an induced pluripotent stem cell, were discovered in 2006.