Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles.
Level 5 - mechanism / opinion, no new human data
Laboratory/ex vivo human skin permeation study without clinical trial data
PubMed 27624531 · doi:10.1684/mrh.2016.0402
What was done
The authors investigated the extent of magnesium ion permeation across human skin following topical application of a magnesium solution, specifically examining the barrier role of the stratum corneum and the contribution of hair follicles to facilitating transdermal transport.
What was found
The abstract reports no numerical values, concentrations, or statistical metrics. It states qualitatively that magnesium ions penetrate human stratum corneum in a manner dependent on concentration and exposure duration, and that hair follicles contribute significantly to penetration.
Why it matters
These findings provide experimental support for transdermal magnesium absorption through human skin, identifying hair follicles as a relevant follicular transport route.
Limits
The abstract provides no sample sizes, donor demographics, magnesium concentrations, exposure durations, or quantitative flux rates. As an in vitro or ex vivo laboratory study, it does not assess systemic bioavailability, clinical efficacy, or safety in living human subjects.
Cited by
- supports Studies suggest that topical magnesium can penetrate the skin through sweat glands and hair follicles.