Breast Cancer Epidemiology and Risk Factors.
Level 5 - mechanism / opinion, no new human data
Narrative review of epidemiology and risk factors without systematic review methodology
PubMed 27681694 · doi:10.1097/GRF.0000000000000239
What was done
This is a narrative review summarizing female breast cancer epidemiology, survival statistics, and risk factors from aggregate population data.
What was found
Between 2010 and 2012, the lifetime probability of developing female breast cancer was 12.3% (approximately 1 in 8). The 5-year relative survival rate between 2005 and 2011 was 89%. Less than 10% of breast cancer cases were attributed to inherited genetic mutations, with the majority associated with environmental, reproductive, and lifestyle factors.
Why it matters
It highlights that the vast majority of breast cancers are linked to non-hereditary, potentially modifiable factors rather than inherited genetic mutations, and contextualizes increasing survival trends.
Limits
As a narrative review, it lacks a systematic literature search or meta-analytic pooling. Specific source populations, sample sizes, confidence intervals, and statistical tests are not reported in the abstract.
Cited by
- supports The average lifetime risk of breast cancer in women is 1 in 8.