Ungaro · Lancet (London, England) 2017 · narrative review · n=?

Ulcerative colitis.

Cited 3539 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review without systematic search methodology or primary data.

PubMed 27914657 · doi:10.1016/S0140-6736(16)32126-2 · record verified 2026-08-29

What was done

This is a narrative review detailing the epidemiology, multifactorial pathogenesis, diagnostic criteria, clinical presentation, and therapeutic options for ulcerative colitis.

What was found

The abstract reports no numerical data or quantitative outcomes. It describes ulcerative colitis as a condition originating in the rectum with continuous proximal extension, presenting typically with bloody diarrhoea, and managed toward resolution of symptoms and endoscopic healing using 5-aminosalicylic acid agents, corticosteroids, immunosuppressants, or colectomy.

Why it matters

It provides a broad clinical overview of standard disease management and highlights that therapeutic options targeting novel pathways are expanding.

Limits

The abstract provides no quantitative effect sizes, search methodology, study inclusion criteria, or direct patient cohort data.

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