Dietary restriction and lifespan: Lessons from invertebrate models.
Level 5 - mechanism / opinion, no new human data
Narrative review of non-human, invertebrate model organism studies
PubMed 28007498 · doi:10.1016/j.arr.2016.12.005
What was done
Narrative review synthesizing evidence on the molecular mechanisms by which dietary restriction influences lifespan across three standard invertebrate model systems: budding yeast (Saccharomyces cerevisiae), the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.
What was found
The abstract reports no quantitative values or effect sizes. It describes conserved roles for nutrient-sensing pathways, specifically mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling, and sirtuins, in mediating lifespan-extending responses to dietary restriction across divergent invertebrate models.
Why it matters
Summarizes key conserved molecular pathways mediating dietary restriction across fundamental laboratory models, outlining core mechanisms that inform geroscience and potential targets.
Limits
The abstract provides no primary data, quantitative synthesis, or sample sizes. Findings are limited to non-human invertebrate organisms, precluding direct clinical application, and protocols for dietary restriction vary substantially across model systems.
Cited by
- supports Caloric restriction reliably extends lifespan in model organisms including yeast and fruit flies, but its effect on lifespan varies across different mouse strains.