Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.
Level 5 - mechanism / opinion, no new human data
Narrative review of mechanisms and dietary interventions without systematic methodology or primary human trial data.
PubMed 28137612 · doi:10.1016/j.mce.2017.01.042
What was done
This narrative review summarizes literature regarding the metabolic regulation of lymphocyte activation, proliferation, and differentiation during autoimmunity and aging, specifically examining the mechanistic impacts of fasting-mimicking diets and other dietary interventions on immunosenescence and autoimmune diseases.
What was found
The abstract reports no numerical findings or effect sizes. It qualitatively describes that organismal metabolic state and nutrient availability determine T-cell fate and function, and that dietary interventions such as fasting-mimicking diets modulate lymphocyte generation, survival, and function.
Why it matters
It highlights the conceptual basis for using targeted dietary interventions and fasting protocols to modulate immune cell metabolism in autoimmune conditions and age-related immune decline.
Limits
The abstract describes a non-systematic narrative review without original clinical data or statistical evidence. No specific patient populations, quantitative outcomes, or comparative effectiveness metrics are reported.
Cited by
- context By roughly day two of a fasting-mimicking diet, the body switches to a ketogenic mode burning visceral fat, the brain uses beta-hydroxybutyrate, and organs including the liver, heart, immune system, and oligodendrocytes shrink.