Regulation of Mammalian Physiology by Interconnected Circadian and Feeding Rhythms.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic biological concepts without empirical data or systematic review methodology.
PubMed 28337174 · doi:10.3389/fendo.2017.00042
What was done
This narrative review synthesized literature on how central (suprachiasmatic nucleus) and peripheral (such as liver) mammalian circadian clocks interact with feeding rhythms to coordinate physiology and tissue-specific gene expression across transcriptional, posttranscriptional, and posttranslational regulatory levels.
What was found
The abstract reports no numerical values or specific quantitative outcomes. It describes that feeding behavior modulates the phase and amplitude of rhythmic peripheral gene expression, highlights that posttranscriptional and posttranslational events can regulate circadian metabolic processes independently of transcriptional oscillations, and notes that circadian or feeding disruptions associate with metabolic diseases.
Why it matters
It emphasizes that meal timing directly influences metabolic signaling networks alongside autonomous circadian clocks, pointing toward chronobiology and scheduled feeding as potential strategies for managing metabolic disorders.
Limits
As a narrative review, it presents broad mechanistic concepts without reporting original human or animal experimental data, quantitative metrics, or systematic search criteria in the abstract.
Cited by
- supports Peripheral circadian clocks in metabolic organs such as the liver and gut are directly synchronized and entrained by the timing of food consumption.