Lee · Progress in cardiovascular diseases 2017 · narrative review · n=?

Running as a Key Lifestyle Medicine for Longevity.

Cited 350 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review without systematic search or meta-analytic pooling

PubMed 28365296 · doi:10.1016/j.pcad.2017.03.005 · record verified 2026-08-30

What was done

The authors reviewed literature examining the impact of running on health outcomes, premature mortality, underlying physiological mechanisms, comparisons with other physical activities, and whether high running volumes attenuate longevity benefits.

What was found

Runners have an estimated 25% to 40% reduced risk of premature mortality and live approximately 3 years longer than non-runners. Specific numerical estimates for dosage thresholds or comparative activities were not provided in the abstract.

Why it matters

The review summarizes epidemiological and mechanistic evidence supporting running as a primary lifestyle intervention for extending life expectancy and reducing chronic disease.

Limits

This is a narrative review with no systematic search criteria, meta-analytic pooling, study count, or sample size reported in the abstract. Findings are derived from observational literature susceptible to healthy-user bias, self-reporting inaccuracies, and residual confounding.

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