Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450.
Level 5 - mechanism / opinion, no new human data
Narrative review of bench and molecular mechanism research with no human clinical data
PubMed 28396637 · doi:10.3389/fphar.2017.00159
What was done
The authors conducted a narrative mini-review summarizing structural and functional data on the four membrane-associated progesterone receptor (MAPR) proteins (PGRMC1, PGRMC2, neudesin/NENF, and neuferricin/CYB5D2), focusing specifically on their biochemical interactions with microsomal cytochrome P450 (CYP) monooxygenase systems.
What was found
The abstract reports no quantitative numerical values. It notes that PGRMC1 shows primarily activating interactions with steroidogenic CYPs (CYP11A1, CYP21A2, CYP17, CYP19, CYP51A1, and CYP61A1), whereas interactions with drug-metabolizing CYPs (CYP2C2, CYP2C8, CYP2C9, CYP2E1, and CYP3A4) are either ineffective or slightly inhibitory. Evidence for CYP interactions with PGRMC2, NENF, and CYB5D2 remains sparse and less conclusive.
Why it matters
This synthesis outlines how MAPRs—particularly PGRMC1—selectively modulate steroidogenesis and drug metabolism pathways, highlighting non-genomic mechanisms of progesterone action and potential targets in metabolic and oncologic disease.
Limits
This is a non-systematic narrative review providing zero human trial data or quantitative pooled estimates. Findings are restricted to bench and in vitro models, and the authors explicitly note that methodological limitations in prior primary studies cast doubt on several historical conclusions.
Cited by
- partial Progesterone plays an important functional role in physiological detoxification pathways.