Zou · The American journal of cardiology 2017 · systematic review and meta-analysis of randomized controlled trials · n=6 studies (269 participants)

Meta-Analysis of Effects of Voluntary Slow Breathing Exercises for Control of Heart Rate and Blood Pressure in Patients With Cardiovascular Diseases.

Cited 64 times in the scientific literature.

Level 1 - systematic review of randomized trials

Systematic review and meta-analysis of randomized controlled trials

PubMed 28502461 · doi:10.1016/j.amjcard.2017.03.247 · record verified 2026-08-28

What was done

Systematic review and meta-analysis of randomized controlled trials searching Embase, PubMed, Cochrane Central Register of Controlled Trials, and PEDro through April 2016. The review evaluated the effect of voluntary slow breathing exercises on resting heart rate, systolic blood pressure, diastolic blood pressure, and training compliance in patients with cardiovascular diseases.

What was found

Across 6 randomized controlled trials comprising 269 subjects with trial durations from 2 weeks to 6 months, slow breathing exercises resulted in statistically significant reductions compared to controls: resting heart rate mean difference of -1.72 beats/min (95% CI -2.70 to -0.75), systolic blood pressure mean difference of -6.36 mm Hg (95% CI -10.32 to -2.39), and diastolic blood pressure mean difference of -6.39 mm Hg (95% CI -7.30 to -5.49). Numeric findings for compliance were not reported in the abstract.

Why it matters

Voluntary slow breathing provides a non-pharmacological adjunct to help lower resting heart rate and blood pressure in patients with cardiovascular disease.

Limits

The total sample size across the 6 included trials is small (269 subjects). Follow-up was limited to short-term durations (2 weeks to 6 months), specific cardiovascular conditions were not broken down in the abstract, and clinical cardiovascular outcomes were not evaluated.

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