Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism.
Level 5 - mechanism / opinion, no new human data
Narrative mechanistic review without systematic methodology or original human data.
PubMed 29086530 · doi:10.4093/dmj.2017.41.5.327
What was done
This narrative review synthesized literature on nonshivering thermogenesis pathways in skeletal muscle, focusing specifically on sarcolipin-mediated uncoupling of sarcoplasmic reticulum calcium ATPase (SERCA) and its contributions to cold-induced and diet-induced thermogenesis.
What was found
The abstract reports no quantitative data or empirical metrics. It describes the physiological rationale that skeletal muscle, as a primary determinant of basal metabolic rate, provides a major avenue for nonshivering thermogenesis via sarcolipin-mediated SERCA uncoupling, which may complement or exceed adipose UCP1-mediated energy expenditure.
Why it matters
Targeting muscle-based nonshivering thermogenesis via sarcolipin-SERCA uncoupling offers an alternative or adjunct biological pathway to brown adipose tissue activation for elevating whole-body energy expenditure in obesity.
Limits
The abstract provides no original experimental data, quantitative effect sizes, or human clinical trial results. As a conceptual narrative review, it discusses proposed mechanistic pathways rather than evaluating therapeutic efficacy or clinical endpoints.
Cited by
- context Muscles are the primary source of heat in the human body.