Magnesium and Human Health: Perspectives and Research Directions.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analysis
PubMed 29849626 · doi:10.1155/2018/9041694
What was done
Narrative review collating published evidence on magnesium physiology, causes of inherited and acquired hypomagnesemia, and clinical correlates across various human health conditions.
What was found
The abstract reports no numerical data, effect sizes, or confidence intervals. It states descriptively that magnesium is a cofactor for over 300 enzymatic reactions, that hypomagnesemia is common in intensive care units and associated with increased mortality and length of stay, and that reduced magnesium levels are associated with chronic conditions including diabetes, osteoporosis, asthma, preeclampsia, migraine, and cardiovascular disease.
Why it matters
It provides a broad overview connecting magnesium deficiency mechanisms with diverse acute and chronic clinical disorders.
Limits
The abstract describes a non-systematic narrative review with no defined search methodology, no quantitative pooling, no risk of bias assessment, and no primary participant data.
Cited by
- supports Magnesium is involved in approximately 300 different biochemical functions in the human body.