Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis.
Level 3 - non-randomized controlled study
Systematic review and meta-analysis of observational genetic association studies
PubMed 29929468 · doi:10.1186/s12879-018-3186-6
What was done
The authors searched four major databases (Medline, PubMed, Embase, and Global Health) to identify genetic association studies investigating dengue or West Nile virus disease, followed by a meta-analysis of identified genetic variants.
What was found
Significant genetic associations were identified for: - West Nile virus disease: OAS1 (meta-OR = 0.83, 95% CI: 0.69-1.00) and CCR5 (meta-OR = 1.29, 95% CI: 1.08-1.53). - Dengue disease: MICB (meta-OR = 2.35, 95% CI: 1.68-3.29), PLCE1 (meta-OR = 0.55, 95% CI: 0.42-0.71), MBL2 (meta-OR = 1.54, 95% CI: 1.02-2.31), and IFN-γ (meta-OR = 2.48, 95% CI: 1.30-4.71).
Why it matters
This meta-analysis highlights specific immune-related host genetic factors linked to severe flavivirus infection outcomes, pointing toward potential shared pathways in disease pathogenesis.
Limits
The abstract notes substantial heterogeneity across included studies in populations, genes examined, and methodology. The number of included studies, total sample size, specific variant alleles, and effect sizes for non-significant variants are not reported in the abstract.
Cited by
- supports CCR5 knockout or null mutations can increase susceptibility to West Nile virus and certain influenza strains.