The impact of exercise and nutrition on the regulation of skeletal muscle mass.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and physiological literature without systematic review methodology.
PubMed 30010196 · doi:10.1113/JP275443
What was done
This narrative review synthesized classical and contemporary research investigating how resistance exercise and nutritional strategies influence muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The authors evaluated different dietary protein sources (whole foods versus supplements), non-protein nutrients such as omega-3 fatty acids, and the application of novel omic technologies (e.g., dynamic protein profiling) to assess protein turnover at the individual protein level.
What was found
The abstract outlines mechanistic pathways through which exercise and nutrition alter MPS and MPB to maintain muscle mass and combat sarcopenia. No quantitative effect sizes, pooled metrics, or statistical values were reported in the abstract.
Why it matters
Understanding the molecular and nutritional determinants of muscle protein turnover helps inform targeted exercise and dietary protocols to counter age-related muscle wasting (sarcopenia) and clinical muscle loss.
Limits
The paper is a non-systematic narrative review with no formal search strategy, study selection protocol, or risk-of-bias assessment. No original experimental data or quantitative comparisons are presented in the abstract.
Cited by
- supports Resistance exercise increases the rate of muscle protein breakdown as well as muscle protein synthesis.