Fragiadakis · Gut microbes 2019 · narrative review and comparative study · n=?

Links between environment, diet, and the hunter-gatherer microbiome.

Cited 174 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review and discussion synthesizing the authors' previous observational findings

PubMed 30118385 · doi:10.1080/19490976.2018.1494103 · record verified 2026-08-30

What was done

The authors synthesized and discussed findings from their research characterizing the gut microbiota of Hadza hunter-gatherers in Tanzania. The paper reviews seasonal shifts in bacterial taxa, diversity, and carbohydrate utilization, compares Hadza profiles with other traditional and industrialized populations globally, and assesses observational data on environmental microbial sources (hands, water, animals), sex and age differences, and short-term agricultural diet additions.

What was found

The abstract reports no numerical values, sample sizes, or effect estimates. The authors report that the Hadza microbiota exhibits seasonal fluctuations in bacterial taxa, overall diversity, and carbohydrate utilization, and shares specific bacterial families with other traditional societies that are rare or absent in industrialized cohorts.

Why it matters

Studying non-industrialized populations provides insight into ancestral human-microbe co-evolution and highlights how industrialization, seasonal foraging, and environmental contact shape gut microbial diversity.

Limits

No sample sizes, statistical measures, or exact numbers are provided in the abstract. The described findings are observational and comparative, precluding causal inference regarding specific dietary or lifestyle interventions.

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