Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic literature without primary data or systematic search methodology
PubMed 30319436 · doi:10.3389/fphys.2018.01307
What was done
This is a narrative review examining literature on exercise-induced myokines (such as IL-6, IL-10, IL-1ra, IL-15, irisin, and myostatin) and their role in mediating biochemical crosstalk between skeletal muscle and adipose tissue in health and metabolic diseases.
What was found
The abstract reports no numerical findings or statistical effect sizes. It qualitatively describes that skeletal muscle contraction releases myokines that mediate anti-inflammatory and pleiotropic health benefits, physical inactivity impairs this response while promoting pro-inflammatory adipokines, and key myokines (IL-6, IL-15, irisin, and myostatin) mediate muscle-adipose communication and adipose tissue browning.
Why it matters
This review outlines the molecular communication network between muscle and adipose tissue, clarifying biological mechanisms through which regular exercise counteracts chronic metabolic and inflammatory diseases.
Limits
This is an unsystematic narrative overview providing no primary human data, sample sizes, or quantitative meta-analytic estimates. The abstract does not report search methodology, study quality criteria, or specific population characteristics.
Cited by
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