Association of facial ageing with DNA methylation and epigenetic age predictions.
Level 4 - case-series / case-control
Cross-sectional observational correlation study
PubMed 30409196 · doi:10.1186/s13148-018-0572-2
What was done
The authors evaluated whether an epigenetic predictor of biological age could be trained using perceived facial age as a surrogate marker. They analyzed the relationship between facial aging, epigenetic clock estimates, and blood-based DNA methylation measures.
What was found
The abstract provides no numerical data, correlation coefficients, or p-values. It states that facial ageing does not correlate with either the epigenetic clock or blood-based DNA methylation measures.
Why it matters
These findings suggest that visually perceived facial aging and blood-based epigenetic clocks reflect independent biological processes rather than a single unified aging measure.
Limits
The abstract omits the sample size, participant demographics, methods used to evaluate facial age, specific epigenetic clock algorithms analyzed, and all underlying statistical values.
Cited by
- contradicts A person's perceived visual age is a strong representation of the biological age and health of their internal organs.