High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search or meta-analytic methodology
PubMed 30540234 · doi:10.1152/physiol.00038.2018
What was done
The authors reviewed literature on how different exercise modalities, specifically high-intensity exercise, stimulate mitochondrial biogenesis in humans, examining ongoing controversies and methodological issues in the field.
What was found
The abstract reports no numerical findings or statistical estimates. It notes that a consensus has not been reached regarding the efficacy of high-intensity exercise to promote human mitochondrial biogenesis due to conflicting results in published studies.
Why it matters
Understanding the exact exercise stimuli required for mitochondrial adaptation informs training prescriptions for health and athletic performance, but methodological variations currently limit clear conclusions.
Limits
The abstract provides no primary human data, sample sizes, or systematic review protocols. Specific sources of methodological conflict are not detailed in the abstract text.
Cited by
- context For equal volumes of exercise, high-intensity interval training yields greater improvements in cardiorespiratory fitness and mitochondrial density compared to zone 2 training.