Amit · Brain research bulletin 1988 · narrative review · n=?

Stress induced analgesia plays an adaptive role in the organization of behavioral responding.

Cited 54 times in the scientific literature.

Level 5 - mechanism / opinion, no new human data

Narrative review and preclinical behavioral/mechanism synthesis

PubMed 3066445 · doi:10.1016/0361-9230(88)90033-0 · record verified 2026-08-29

What was done

The authors conducted a narrative review of literature and experimental paradigms evaluating stress-induced analgesia (SIA), its underlying opioid and non-opioid mechanisms, and its conditioning properties. They also summarized a series of experiments from their own laboratory examining how SIA induction modulates behavioral performance and learning under varying levels of threat.

What was found

The abstract reports no quantitative values or statistical metrics. Qualitatively, it reports that stimuli inducing SIA do not necessarily need to be overtly aversive or stressful. SIA involves semi-independent opioid and non-opioid mechanisms that are subject to differential conditioning. Additionally, SIA interacts with behavioral performance along an inverted U-shaped curve, where low stress levels facilitate responding and learning, while high stress levels disrupt them.

Why it matters

The review provides a theoretical framework framing pain suppression during stress as an organized, adaptive behavioral mechanism that optimizes an organism's survival during threatening encounters, rather than an incidental consequence of trauma.

Limits

The abstract provides no quantitative data, effect estimates, sample sizes, or description of a systematic literature search. Findings are based on preclinical animal models and narrative synthesis, limiting direct translation to clinical human pain processing.

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