Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.
Level 5 - mechanism / opinion, no new human data
Narrative review without systematic search methodology or primary data
PubMed 30712977 · doi:10.1016/j.tem.2019.01.006
What was done
This is a narrative review examining the pleiotropic regulatory effects of the ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) on inflammation, oxidative stress, and gene expression, focusing on the anticatabolic role of βHB in skeletal muscle.
What was found
The abstract reports no quantitative data, sample sizes, or numerical outcomes. It describes qualitatively that β-hydroxybutyrate demonstrates anticatabolic actions in human skeletal muscle during inflammatory insult.
Why it matters
It highlights a mechanistic rationale for using nutritional ketosis or ketone body supplementation to prevent inflammation-induced muscle wasting.
Limits
The abstract provides no primary empirical data, study designs, participant counts, or effect estimates. As a narrative review summary, it does not detail the specific inflammatory models or dosing protocols used.
Cited by
- supports Ketone ester supplementation elevating both beta-hydroxybutyrate and acetoacetate prevents muscle wasting in experimental models of cachexia.