Harnessing Metal Homeostasis Offers Novel and Promising Targets Against Candida albicans.
Level 5 - mechanism / opinion, no new human data
Narrative review discussing fungal micronutrient mechanisms with no original human data.
PubMed 30827249 · doi:10.2174/1570163816666190227231437
What was done
This paper is a narrative review summarizing mechanisms of micronutrient availability, host nutritional immunity, and fungal adaptation pathways in Candida albicans, with an emphasis on identifying potential targets to reverse multidrug resistance.
What was found
The abstract provides no quantitative data or specific numerical results. It outlines conceptual mechanisms regarding how Candida albicans acquires micronutrients from host reservoirs and identifies these processes as potential therapeutic targets.
Why it matters
As multidrug-resistant Candida infections rise in immunocompromised patients, mapping metal homeostasis mechanisms provides conceptual frameworks for developing novel antifungal drug targets.
Limits
The abstract describes a narrative review containing no original clinical or empirical data. No specific interventions, quantitative outcomes, or systematic literature search parameters are reported.
Cited by
- supports Zinc helps reduce yeast and fungus, and copper is an antifungal agent also used in agriculture.