Nutrigenomics of Vitamin D.
Level 5 - mechanism / opinion, no new human data
Narrative review summarizing molecular mechanisms without primary empirical data or systematic search
PubMed 30901909 · doi:10.3390/nu11030676
What was done
This narrative review summarizes the genomic mechanisms of vitamin D, describing how its active metabolite, 1α,25-dihydroxyvitamin D₃, binds the vitamin D receptor to modulate the human epigenome and transcriptome. It synthesizes conceptual and mechanistic insights regarding calcium homeostasis, innate and adaptive immunity, evolutionary skin pigmentation, and personalized supplementation strategies.
What was found
The abstract reports no empirical data, sample sizes, or quantitative outcome measures. It provides a descriptive overview that active vitamin D regulates thousands of genomic loci involved in immune response and cellular metabolism.
Why it matters
It highlights vitamin D's function as a widespread epigenetic and transcriptomic regulator, offering a mechanistic framework for personalized supplementation strategies in metabolic, autoimmune, and musculoskeletal conditions.
Limits
This is a narrative review with no primary empirical human data, quantitative outcome measures, or systematic search methodology. It provides no clinical trial evidence evaluating specific personalized dosing regimens on clinical endpoints.
Cited by
- supports Active vitamin D is converted into a steroid hormone that modulates approximately 5% of the human genome.