Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic physiology with no original empirical data
PubMed 31217327 · doi:10.1042/BCJ20180617
What was done
This narrative review summarizes mechanisms of cardiac mitochondrial energy metabolism and regulation based on existing literature. It describes cardiac substrate utilization pathways and reviews regulatory mechanisms, including allosteric control by short-chain coenzyme A esters such as malonyl-CoA, transcriptional regulation during postnatal maturation and metabolic adaptation, and post-translational modifications including phosphorylation, acetylation, malonylation, succinylation, and glutarylation.
What was found
The abstract reports typical baseline values for cardiac ATP generation: mitochondrial oxidative phosphorylation contributes 95% while cytosolic glycolysis contributes 5%. Energy substrate shares for ATP production are reported as fatty acids (40-60%), glucose (20-40%), ketones (10-15%), and amino acids (1-2%). No original empirical data, effect estimates, or statistical comparisons are reported.
Why it matters
It outlines how myocardial mitochondria coordinate substrate selection and rate of ATP production to accommodate dynamic contractile demands across varying physiological conditions.
Limits
This is a narrative review with no original experimental or clinical data, no systematic search protocol, and no primary quantitative outcomes.
Cited by
- context Mitochondria have a preference for utilizing fat as fuel over glucose.