Choline: Exploring the Growing Science on Its Benefits for Moms and Babies.
Level 5 - mechanism / opinion, no new human data
Narrative review of animal and human literature without systematic search methodology.
PubMed 31394787 · doi:10.3390/nu11081823
What was done
This paper provides a narrative review summarizing the physiological roles of choline during pregnancy, the existing evidence from animal and human studies on maternal supplementation, and population-level intake patterns among pregnant women in the United States.
What was found
The abstract reports no quantitative trial outcomes or statistical effect sizes. It notes that choline is essential for membrane biosynthesis, brain development, and methyl donation, and highlights that most pregnant women in the United States do not achieve the recommended intake of 450 mg/day.
Why it matters
It highlights an unmet nutritional target in prenatal care and outlines the biological rationale for increasing dietary or supplemental choline intake during pregnancy.
Limits
The abstract provides no original empirical data, quantitative effect estimates, or systematic review methodology. Specific doses, adverse effect profiles, and variations across different trimesters are not detailed in the abstract.
Cited by
- supports The recommended dietary intake of choline for pregnant women is approximately 450 milligrams per day.