Lee · Proceedings of the National Academy of Sciences of the United States of America 2019 · prospective cohort study · n=?

Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women.

Cited 196 times in the scientific literature.

Level 3 - non-randomized controlled study

Prospective longitudinal cohort study

PubMed 31451635 · doi:10.1073/pnas.1900712116 · record verified 2026-08-29

What was done

Researchers assessed the relationship between baseline optimism and exceptional longevity (survival to age 85 or older) across two prospective cohorts: female nurses from the Nurses' Health Study (NHS, 10-year follow-up, 2004–2014) and male veterans from the Veterans Affairs Normative Aging Study (NAS, 30-year follow-up, 1986–2016). Optimism was measured with the Life Orientation Test-Revised (NHS) and the Revised Optimism-Pessimism Scale from the MMPI-2 (NAS). Accelerated failure time models and logistic regression were used, adjusting for demographic confounders, health conditions, and health behaviors.

What was found

In both cohorts, higher optimism showed a dose-dependent association with increased longevity (P trend < 0.01). Adjusted for demographics and health conditions, women in the highest versus lowest optimism quartile had a 14.9% (95% CI, 11.9 to 18.0) longer lifespan, with similar results observed in men. Individuals in the highest versus lowest optimism groups had 1.5 (women) and 1.7 (men) greater odds of surviving to age 85, which remained significant after adjusting for health behaviors.

Why it matters

This study shows that psychological optimism is independently associated with exceptional longevity, indicating that psychosocial factors may serve as potential targets in healthy aging strategies.

Limits

Participant sample sizes (n) were not reported in the abstract. The study is observational, precluding causal inference. Different psychometric instruments were used to assess optimism in each cohort, and the cohorts (nurses and veterans) may not be representative of the general population.

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