Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.
Level 5 - mechanism / opinion, no new human data
Narrative review synthesizing mechanistic and preclinical concepts without systematic review methodology.
PubMed 31784171 · doi:10.1016/j.scitotenv.2019.135624
What was done
The authors summarized existing literature on sulforaphane, a sulfur-rich dietary phytochemical, examining its ability to activate the nuclear factor erythroid 2 related factor 2 (Nrf2) signaling pathway and its proposed therapeutic relevance across acute and chronic neurological disorders.
What was found
The abstract reports no numerical data, effect sizes, or counts of reviewed studies. It qualitatively describes sulforaphane as an activator of the Nrf2 cascade that promotes cytoprotective enzyme expression, targeting common pathogenic pathways such as oxidative stress, mitochondrial dysfunction, neuroinflammation, excitotoxicity, protein misfolding, and neuronal damage.
Why it matters
It organizes mechanistic rationale supporting sulforaphane as a dietary candidate to stimulate endogenous antioxidant and anti-inflammatory defenses in neurodegenerative diseases.
Limits
The paper is a non-systematic narrative review providing no quantitative synthesis or risk-of-bias evaluation. The abstract reports no clinical trial findings or human outcome data, relying primarily on mechanistic and preclinical assertions.
Cited by
- supports Sulforaphane strongly activates the Nrf2 stress response pathway that upregulates detoxification genes.