A Brief History of Nutritional Rickets.
Level 5 - mechanism / opinion, no new human data
Narrative historical review without systematic search methodology or primary empirical data.
PubMed 31798536 · doi:10.3389/fendo.2019.00795
What was done
This narrative review outlines the history of nutritional rickets, tracing early understandings of its etiology, historical public health uses of vitamin D preparations for prevention and treatment, and contemporary management guidelines.
What was found
The abstract reports no numerical or quantitative data. It highlights that nutritional rickets persists as a major public health concern despite established preventative tools, noting that serious extraskeletal manifestations, such as hypocalcemic seizures and cardiomyopathy, cause documented fatalities.
Why it matters
The paper contextualizes the ongoing global burden of an entirely preventable disease to support the adoption of global consensus recommendations for vitamin D supplementation and public health interventions.
Limits
This is a narrative historical review without systematic literature search methods, statistical pooling, or original empirical data. The abstract lacks quantitative metrics on incidence, prevalence, or intervention efficacy.
Cited by
- supports Vitamin D deficiency in infants can cause structural problems such as scoliosis, kyphosis, flat feet, and maxillary malformations requiring braces.