Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy.
Level 4 - case-series / case-control
Cross-sectional observational study
PubMed 31819568 · doi:10.2147/DMSO.S210616
What was done
A cross-sectional study evaluated 223 adults with class III obesity categorized as metabolically healthy obesity (MHO) or metabolically unhealthy obesity (MUHO) according to NCEP-ATP III criteria. Anthropometric, biochemical, and clinical variables—including HOMA-IR, visceral adiposity index, inflammatory markers, and bone markers—were analyzed and compared between groups.
What was found
Of 223 participants, 32.73% were classified as MHO and 67.26% as MUHO. HOMA-IR was significantly higher in the MUHO group (p=0.003), while visceral adiposity index was significantly lower in the MHO group (p=0.001). BMI correlated positively with phosphorus (r=0.31, p<0.001) and negatively with 25(OH)D (r=-0.31, p=0.041). In the MHO group, negative correlations occurred between calcium and C-reactive protein (r=-0.30, p=0.017) and between parathyroid hormone and HOMA-IR (r=-0.28, p=0.017).
Why it matters
The findings demonstrate that even individuals with class III obesity classified as metabolically healthy show underlying metabolic alterations, underscoring the need for longitudinal clinical surveillance.
Limits
The cross-sectional design cannot evaluate longitudinal progression or causality. The sample is limited to adults with class III obesity (n=223) and abstract does not detail demographic characteristics, recruitment methods, or medication use.
Cited by
- supports Some individuals with a BMI over 40 have normal insulin, blood sugar, lipids, low hs-CRP, and no apparent chronic disease.